1260909-30-5

Upstream product

• 857489-17-9 N-(1-phenylethenyl)benzamide 
• 1190763-76-8 (4-bromophenyl)(1H-indol-3-yl)methanol 
• 120-72-9 indole 
• 1774-66-9 3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 73654-15-6 (Z)-3-(4-Bromo-phenyl)-1-phenyl-propenone 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of indole derivatives as novel α-glucosidase inhibitors in vitro

Indole containing compounds have acquired conspicuous significance due to their wide spectrum of biological activities. Synthesis of a series of enantiomerically pure indole derivatives 3a-r via Friedel–Crafts alkylation of indole 1 with enones 2a-r were described here. The products were isolated in a moderate to excellent yields (upto 89%) with excellent enantioselectivities (upto 99.9% ee). These compounds 3a-r were evaluated for their in vitro α-glucosidase inhibitory activity and some of them were identified as potent inhibitors (IC50 = 4.3 ± 0.13–43.9 ± 0.51 μM) with several fold higher activity than the clinically used α-glucosidase inhibitor, acarbose (IC50 = 840 ± 1.73 μM). To the best of knowledge, this is the first report of the propanone substituted indole ring containing compounds by in vitro α-glucosidase enzyme inhibition.

Chiral Bronsted acid catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones: Short access to optically active 2- and 3-substituted indole derivatives

The asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones catalyzed by chiral phosphoric acid is reported. A wide range of indoles and 4,7-dihydroindoles were allowed to react with α,β-unsaturated ketones to give the corres

Highly enantioselective alkylation reaction of enamides by bronsted-acid catalysis

The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with Indoiyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric α-alkylation of enamides with indoiy