126091-24-5

Usage

Uses

Used in Chemical Research:
3'-Trifluoromethylbiphenyl-3-carbaldehyde is used as a research compound for its unique properties in chemical reactions, particularly due to the presence of the trifluoromethyl and carbaldehyde groups.
Used in Pharmaceutical Industry:
3'-Trifluoromethylbiphenyl-3-carbaldehyde is used as an intermediate in the synthesis of complex pharmaceutical compounds, leveraging its distinctive characteristics for custom synthesis and method development.
Used in Material Science:
3'-Trifluoromethylbiphenyl-3-carbaldehyde is used as a building block in the development of new materials, taking advantage of its unique chemical properties to create novel compounds with potential applications in various industries.

Upstream product

• 126091-22-3 3-(3-Trifluoromethyl-phenyl)-8-oxa-bicyclo[3.2.1]oct-3-en-6-one 
• 262268-58-6 (E)-3-(3-(trifluoromethyl)phenyl)acrylaldehyde 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 58606-65-8 N-[(3-fluorophenyl)methylidene]aniline 
• 126091-21-2 (1R,3S,5S)-3-(3-Trifluoromethyl-phenyl)-8-oxa-bicyclo[3.2.1]oct-6-en-3-ol 

Relevant academic research and scientific papers

Microwave-assisted organic acid-base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides

A novel organic acid-base-co-catalyzed conversion of styrylepoxides into [1,1′-biaryl]-3-carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1′-biaryl]-3-carbaldehydes.

Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands

A highly general and selective Co-catalyzed biaryl coupling through C-F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C-F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C-Cl or C-Br bonds could also be achieved.

NEW ROUTES TO SUBSTITUTED TROPONES

We descibe the synthesis of various mono- and di-substituted tropones from 8-oxabicyclooctenones, and also two novel cleavage reactions of these oxabicycles.

Rearrangement of Aryl-8-oxabicyclooctenones: Synthesis of Novel Biaryls and 1-Aryl-3-furylpropanones

The formation of 3-arylbenzaldehydes through rearrangement of 3-aryl-8-oxabicyclooct-2-en-7-ones is reported, together with various rearrangement reactions of 2-aryl-8-oxabicyclooct-6-en-3-ones, and a novel approach to the natural product acamelin.