1261060-26-7

Basic information

• Product Name: (S,Z)-tert-butyl 4-(2-isocyano-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate
• Synonyms: (S,Z)-tert-butyl 4-(2-isocyano-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate
• CAS NO: 1261060-26-7
• Molecular Weight: 358.437
• Mol File: 1261060-26-7.mol

Chemical Properties

• CAS DataBase Reference: (S,Z)-tert-butyl 4-(2-isocyano-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S,Z)-tert-butyl 4-(2-isocyano-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate(1261060-26-7)
• EPA Substance Registry System: (S,Z)-tert-butyl 4-(2-isocyano-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate(1261060-26-7)

Safety Data

• Hazardous Substances Data: 1261060-26-7(Hazardous Substances Data)

Upstream product

• 173065-16-2 (4S)-4-ethynyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 153898-63-6 2-iodo-5-methoxyaniline 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 130418-98-3 (S)-tert-butyl 4-(2,2-dibromovinyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 1261060-24-5 (S)-tert-butyl 4-((2-formamido-4-methoxyphenyl)ethynyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 1261060-23-4 N-(2-iodo-5-methoxyphenyl)formamide 
• 1261060-25-6 (S,Z)-tert-butyl 4-(2-formamido-4-methoxystyryl)-2,2-dimethyloxazolidine-3-carboxylate 

Downstream Products

• 171864-80-5 Tryprostatin A 

Relevant articles and documents

Total synthesis of tryprostatins A and B

Three distinct synthetic routes to the 2-prenyl tryptophan core skeleton of tryprostatins and their total syntheses are described. The strategies include a traditional gramine-mediated coupling reaction, Fuerstner indole synthesis, and our radical-mediated indole synthesis from o-alkenylphenyl isocyanide. The establishment of reliable conditions for the radical-mediated construction of indoles via a low-temperature radical initiator V-70 (2,2′-azobis(4- methoxy-2,4-dimethylvaleronitrile)) led to the highly efficient syntheses of tryprostatins A and B.

Total synthesis of tryprostatins a and b

A reasonable approach to the radical: The establishment of reliable conditions for the radical-mediated construction of indoles enabled the highly efficient synthesis of tryprostatins A and B. Use of the radical initiator 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) has allowed to carry out the radical cyclization at just 30°C, thereby suppressing the formation of by-products. Copyright