1261080-62-9

Basic information

• Product Name: (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide
• Synonyms: (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide
• CAS NO: 1261080-62-9
• Molecular Weight: 463.35
• Mol File: 1261080-62-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide(1261080-62-9)
• EPA Substance Registry System: (S)-N-(1-azido-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide(1261080-62-9)

Safety Data

• Hazardous Substances Data: 1261080-62-9(Hazardous Substances Data)

Upstream product

• 866524-08-5 (S)-1-azido-3-(2,4-dichlorophenyl)-2-aminopropane 
• 1261080-61-8 2-(2-(methylamino)pyrimidin-4-yl) thiazole-5-carboxylic acid 
• 1357194-46-7 (S)-1-azido-3-(2,4-dichlorophenyl)propan-2-amine hydrochloride 
• 1261080-60-7 methyl 2-(3-(dimethylamino)acryloyl) thiazole-5-carboxylate 
• 1261080-59-4 methyl 2-acetylthiazole-5-carboxylate 

Downstream Products

• 1261080-40-3 (S)-N-(1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)thiazole-5-carboxamide 

Relevant articles and documents

5 - thiazole amides and biological applications

The invention relates to a 5-thiazole amide compound and biology application thereof. The 5-thiazole amide compound has a general formula (I) described in the specification and is used for targeting an AKT/PKB kinase (ATP binding site). Experiments prove that a thiazole amide AKT inhibitor can remarkably inhibit the activity of the AKT kinase in vitro and has strong proliferation inhibition function on various tumor cells with high AKT activity, which indicate that the 5-thiazole amide compound can be used for preparing drugs for resisting tumors.