1261084-72-3Relevant academic research and scientific papers
Rigid spiroethers targeting the decoding center of the bacterial ribosome
Mavridis, Ioannis,Kythreoti, Georgia,Koltsida, Konstantina,Vourloumis, Dionisios
, p. 1329 - 1341 (2014/03/21)
Continuing our efforts towards understanding the principles governing ribosomal recognition and function, we have synthesized and evaluated a series of diversely functionalized 5,6-, 6,6- and 7,6-spiroethers. These compounds successfully mimic natural aminoglycosides regarding their binding to the decoding center of the bacterial ribosome. Their potential to inhibit prokaryotic protein production in vitro along with their antibacterial potencies have also been examined.
Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome
Stathakis, Christos I.,Mavridis, Ioannis,Kythreoti, Georgia,Papakyriakou, Athanasios,Katsoulis, Ioannis A.,Cottin, Thomas,Anastasopoulou, Panoula,Vourloumis, Dionisios
scheme or table, p. 7488 - 7492 (2011/01/12)
Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and exten
