126120-87-4

Basic information

• Product Name: 2,2-DIFLUORO-BENZO[1,3]DIOXOLE-4-BORONIC ACID
• Synonyms: 2,2-DIFLUORO-BENZO[1,3]DIOXOLE-4-BORONIC ACID;2,2-Difluorobenzo[1,3]dioxole-4-voronic acid;3-Borono-1,2-(difluoromethylenedioxy)benzene;2,2-Difluorobenzo[d][1,3]dioxole-4-ylboronic acid;2,2-Difluoro-1,3-benzodio...;(2,2-Difluorobenzo[d][1,3]dioxol-4-yl)boronic acid;2,2-Difluoro-1,3-benzodioxole-4-boronic acid 98%;2,3-(Difluoromethylenedioxy)benzeneboronic acid, 4-Borono-2,2-difluoro-1,3-benzodioxole
• CAS NO: 126120-87-4
• Molecular Formula: C₇H₅BF₂O₄
• Molecular Weight: 201.92
• Mol File: 126120-87-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 299°C at 760 mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0.000549mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.80±0.40(Predicted)
• CAS DataBase Reference: 2,2-DIFLUORO-BENZO[1,3]DIOXOLE-4-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-BENZO[1,3]DIOXOLE-4-BORONIC ACID(126120-87-4)
• EPA Substance Registry System: 2,2-DIFLUORO-BENZO[1,3]DIOXOLE-4-BORONIC ACID(126120-87-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 126120-87-4(Hazardous Substances Data)

Usage

Uses

2,2-Difluorobenzo[1,3]dioxole-4-boronic acid

InChI:InChI=1/C7H5BF2O4/c9-7(10)13-5-3-1-2-4(8(11)12)6(5)14-7/h1-3,11-12H

Upstream product

• 1583-59-1 2,2-difluoro-1,3-benzodioxole 
• 121-43-7 Trimethyl borate 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 7732-18-5 water 
• 144584-66-7 4-bromo-2,2-difluoro-1,3-benzodioxole 

Downstream Products

• 131341-86-1 Fludioxonil 
• 1092476-50-0 (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-(4-methyl-1-piperazinyl)acetohydrazide 
• 1613713-01-1 C₃₄H₃₃F₂N₅O₆S 
• 875639-20-6 3-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1613712-88-1 C₂₈H₂₂F₂N₄O₅S₂ 
• 1613712-87-0 C₃₁H₂₇F₂N₃O₄S₂ 
• 1613712-86-9 C₃₀H₂₅F₂N₃O₄S₂ 
• 1613712-85-8 C₃₂H₂₉F₂N₃O₆S₂ 
• 1613712-84-7 C₂₈H₂₂F₂N₄O₅S₂ 
• 1613712-83-6 C₃₀H₂₅F₂N₃O₅S₂ 
• 1613711-10-6 N-(tert-butyl)-3-(3-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-methylbenzenesulfonamide 
• 1112662-77-7 C₂₁H₁₃BrF₂N₂O₄S 
• 1190058-32-2 N-(7-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 

Relevant articles and documents

Synthesis of Pyrroles via Consecutive 6π-Electrocyclization/Ring-Contraction of Sulfilimines

We present a modular, synthetic entry to polysubstituted pyrroles employing readily available 2,5-dihydrothiophenes. Ring-opening of the heterocycle provides access to a panel of 1,3-dienes which undergo pyrrole formation in the presence of inexpensive chloramine-T trihydrate. The transformation is conducted in an open flask and proceeds at ambient temperatures (23 °C) in nondry solvents. A careful adjustment of the electronics and sterics of the 1,3-diene precursor allows for the isolation of key intermediates. DFT studies identified a reaction mechanism that features a 6π-electrocyclization of a sulfilimine intermediate followed by spontaneous ring-contraction to reveal the pyrrole skeleton.

NOVEL COMPOUNDS

The invention provides compounds of formula (I): Said compounds being modulators of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.