1261244-86-3

Upstream product

• 183486-17-1 4-[(2-hydroxy-3-methoxy-benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 7732-18-5 water 
• 58732-04-0 4-(2-hydroxynaphthalen-1-ylmethylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 
• 30957-66-5 4-(2-hydroxybenzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 

Relevant academic research and scientific papers

New Ru(II)-DMSO complexes of ON/SN chelates: Synthesis, behavior of Schiff bases towards hydrolytic cleavage of CN bond, electrochemistry and biological activities

The reaction of cis-[RuCl2(DMSO)4] with salicylaldehyde semicarbazone in ethanol resulted in the chemoselective cleavage of the CN bond of the Schiff base, forming a complex in which the semicarbazide remains coordinated to the metal, as observed previously with trans-[RuCl 2(DMSO)4]. In another set of reactions of cis-[RuCl 2(DMSO)4] with 4-aminoantipyrine derivatives of salicylaldehyde, 2-hydroxy-1-naphthaldehyde and o-vanillin, CN cleavage was observed in all three cases yielding the same compound, [RuCl 2(DMSO)2(4-aminoantipyrine)]. However, when the reactions, under the same experimental conditions, were extended to unsubstituted/N- substituted thiosemicarbazones of salicylaldehyde and 2-hydroxy-1- naphthaldehyde, no cleavage was observed. All the new complexes were characterized by analytical and spectroscopic techniques. The structures of two of the complexes, [RuCl2(DMSO)2(semicarbazide)] ·2H2O and [RuCl2(DMSO)2(4- aminoantipyrine)], were determined by single crystal XRD and are in support of the cleavage. The electrochemistry of the complexes was studied by cyclic voltammetry. Further, the preliminary DNA-binding ability and antibacterial activity of the complexes were studied.