1261252-45-2Relevant academic research and scientific papers
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to lead
Siu, Tony,Kozina, Ekaterina S.,Jung, Joon,Rosenstein, Craig,Mathur, Anjili,Altman, Michael D.,Chan, Grace,Xu, Lin,Bachman, Eric,Mo, Jan-Rung,Bouthillette, Melaney,Rush, Thomas,Dinsmore, Christopher J.,Marshall, C. Gary,Young, Jonathan R.
scheme or table, p. 7421 - 7425 (2011/02/23)
This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study.
