1261267-46-2Relevant academic research and scientific papers
A recyclable organocascade reaction system: Stereoselective precipitation of optically active cis-δ-lactols with quaternary stereocenters during the Michael-hemiacetalization reaction
Zhang, Fanglin,Wei, Mohui,Dong, Junfang,Zhou, Yirong,Lu, Dengfu,Gong, Yuefa,Yang, Xiangliang
supporting information; experimental part, p. 2875 - 2880 (2011/01/05)
A cascade Michael-hemiacetalization reaction between β-substituted β-nitroethanols and α,β-unsaturated aldehydes is described, which provides a convenient and efficient synthesis for cis-δ-lactols with quaternary stereocenters in moderate yields with excellent enantioselectivity. Based on the selective precipitation of cis-δ-lactols, which were isolated by filtration, the catalytic system in the filtrate can be reused directly and recycled for eight times without any obvious deterioration in enantioselectivity. Copyright
