1261296-11-0

Basic information

• Product Name: (S)-5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl 2-acetamido-3-phenylpropanoate
• CAS NO: 1261296-11-0
• Molecular Weight: 505.785
• Mol File: 1261296-11-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl 2-acetamido-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl 2-acetamido-3-phenylpropanoate(1261296-11-0)
• EPA Substance Registry System: (S)-5-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl 2-acetamido-3-phenylpropanoate(1261296-11-0)

Safety Data

• Hazardous Substances Data: 1261296-11-0(Hazardous Substances Data)

Upstream product

• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 58622-66-5 4-chloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide 

Relevant articles and documents

New amino acid esters of salicylanilides active against MDR-TB and other microbes

Eleven halogenated (S)-2-(phenylcarbamoyl)phenyl 2-acetamido-3- phenylpropanoates (3a-3k) were designed and synthesized as potential antimicrobial agents. They were evaluated in vitro against some mycobacterial, bacterial and fungal strains. These compounds were active against drug-sensitive and atypical mycobacterial strains with general MIC values from 0.25 to 16 μmol/L. The most active compounds were (S)-4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl)phenyl 2-acetamido-3-phenylpropanoate (3i) and (S)-4-bromo-2-(4-(trifluoromethyl)phenylcarbamoyl)phenyl 2-acetamido-3- phenylpropanoate (3k) which exhibited activity against MDR and XDR-TB strains with MICs from 1 to 2 μmol/L. 3k was shown to be less cytotoxic with higher IC50. Some compounds exhibited low MICs on Gram-positive bacteria (MICs ≥ 0.98 μmol/L) and on fungi (MICs ≥ 3.9 μmol/L).