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1261297-33-9

cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1261297-33-9 Structure

  • Basic information

    1. Product Name: cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone
    2. Synonyms: cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone
    3. CAS NO:1261297-33-9
    4. Molecular Formula:
    5. Molecular Weight: 395.542
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1261297-33-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone(1261297-33-9)
    11. EPA Substance Registry System: cyclopropyl{4-[4-(2-(diisopropylamino)ethoxy)benzyloxy]phenyl}methanone(1261297-33-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1261297-33-9(Hazardous Substances Data)

1261297-33-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1261297-33-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,1,2,9 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1261297-33:
(9*1)+(8*2)+(7*6)+(6*1)+(5*2)+(4*9)+(3*7)+(2*3)+(1*3)=149
149 % 10 = 9
So 1261297-33-9 is a valid CAS Registry Number.

1261297-33-9Relevant articles and documents

Synthesis and optimization of antitubercular activities in a series of 4-(aryloxy)phenyl cyclopropyl methanols

Bisht, Surendra S.,Dwivedi, Namrata,Chaturvedi, Vinita,Anand, Namrata,Misra, Mridul,Sharma, Rahul,Kumar, Brijesh,Dwivedi, Richa,Singh, Shyam,Sinha, Sudhir Kumar,Gupta, Versha,Mishra,Dwivedi, Anil K.,Tripathi, Rama P.

, p. 5965 - 5978 (2010)

A series of [4-(aryloxy)phenyl]cyclopropyl methanones were synthesized by reaction of different benzyl alcohols with 4-chloro-4′-fluorobutyrophenone in DMF in the presence of NaH/TBAB. The methanones were further reduced to respective methanols. The antitubercular activity of these compounds was evaluated in vitro against Mycobacterium tuberculosis H37Rv. Compounds 19, 21, 35, 36 and 37 have shown minimum inhibitory concentration (MIC) of 3.12 μg/mL, while compounds 14, 25 and 18 have shown MIC of 1.56 μg/mL and 0.78 μg/mL respectively. One of the compounds, cyclopropyl-4-[4-(2-piperidin-1- yl-ethoxy)benzyloxy]phenyl}methanol (36) showed 98% killing of intracellular bacilli in mouse bone marrow derived macrophages and was active against MDR, XDR and rifampicin clinical isolates resistant strains with MIC 12.5 μg/mL. Compound 36 was orally active in vivo in mice against M. tuberculosis H37Rv with an increase in MST by 6 days with 1 log reduction in the bacillary density in lungs as compared to control on 30th day after infection.

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