1261301-22-7Relevant academic research and scientific papers
Immobilization of a modified tethered rhodium(III)-p-toluenesulfonyl-1,2- diphenylethylenediamine catalyst on soluble and solid polymeric supports and successful application to asymmetric transfer hydrogenation of ketones
Dimroth, Jonas,Keilitz, Juliane,Schedler, Uwe,Schomaecker, Reinhard,Haag, Rainer
, p. 2497 - 2506 (2010)
Catalyst immobilization through covalent attachment onto a support is one strategy to provide recyclable systems. Here, soluble and surface-functionalized solid polymers were used as supports for a modified tethered rhodium(III)-p-toluenesulfonyl-1,2-diphenylethylenediamine [Rh(III)-TsDPEN] complex. The supported catalysts were applied to the asymmetric transfer hydrogenation of phenyl ketones in aqueous solution of sodium formate. High ee values (up to 99%) and good activities were achieved. It was discovered that the solid polymer-supported catalyst could be recycled at least four times without a significant decrease of the activity when a mixture of sodium formate and formic acid was used as the hydrogen source. This catalytic system provides a promising approach towards an ecologically and economically rational production of enantioenriched building blocks.
