126133-58-2

Upstream product

• 72-19-5 L-threonine 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 126133-75-3 N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-galactopyranosyl)-(1<*>3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin 
• 126133-73-1 N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester 
• 126133-71-9 N-Allyloxycarbonyl-O-<(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1<*>3)-O-(2-azido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl)>-L-threonin-tert-butylester 
• 149203-56-5 (2S,3R)-2-Allyloxycarbonylamino-3-(diphenoxy-phosphoryloxy)-butyric acid methylsulfanylmethyl ester 

Relevant academic research and scientific papers

Synthesis of Norfijimycin A with Activity against Mycobacterium tuberculosis

The total synthesis of norfijimycin A, a simplified analogue of the marine natural product fijimycin A, is described. Fijimycin A is a cyclic depsipeptide that has been shown to possess activity against methicillin-resistant Staphylococcus aureus. The natural product contains a rare N,β-dimethyl leucine unit with unknown stereochemistry at the β-carbon. To evaluate the importance of the β-methyl group for antimicrobial activity, we introduced N-methyl leucine into the natural product scaffold. The resulting norfijimycin A was shown to possess significant activity against Mycobacterium tuberculosis, the etiological agent of tuberculosis.

Synthesis of L-Proline-Containing O-Glycopeptides

The synthesis of a number of L-proline-containing O-glycopeptides in which 2-acetamido-2-deoxy-α-D-galacto-pyranose is α-glycosidically linked to L-threonine is described.For N-terminal extension with amino acids the building block 3 is preferred.For C-te