1261445-68-4Relevant academic research and scientific papers
Characterization, synthesis and self-aggregation of (-)-alternarlactam: A new fungal cytotoxin with cyclopentenone and isoquinolinone scaffolds
Zhang, Ai Hua,Jiang, Nan,Gu, Wen,Ma, Jing,Wang, Yu Rong,Song, Yong Chun,Tan, Ren Xiang
, p. 14479 - 14485 (2011/03/21)
(-)-Alternarlactam [(-)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality-activity relevance and self-aggregation of (-)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents. Double the framework: The absolute configuration, chirality-activity relevance and self-aggregation of (-)-alternarlactam [(-)-1], a cytotoxin from Alternaria sp. HG1 culture with double antitumor pharmacophores in a new framework, were assigned by a combination of synthetic, spectroscopic and computational approaches. Copyright
