126146-63-2Relevant academic research and scientific papers
Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: Cholesterol acyltransferase
Kwon, Byoung-Mog,Ro, Sook-Hee,Kim, Mi-Kyung,Nam, Ji-Youn,Jung, Hyun-Ju,Lee, Ihn-Rhan,Kim, Young-Kook,Bok, Song-Hae
, p. 552 - 553 (1997)
In the course of our screening program for acylCoA:cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC50 values of 94, 80, 45 and 79 μM, respectively.
POLYACETYLENES FROM THE ROOTS OF PANAX GINSENG
Hirakura, Kazuhiro,Morita, Makoto,Nakajima, Kaoru,Ikeya, Yukinobu,Mitsuhashi, Hiroshi
, p. 3327 - 3333 (1991)
Key Word Index - Panax ginseng; Araliaceae; polyacetylene; ginsenoyne A; ginsenoyne B; ginsenoyne C; ginsenoyne D; ginsenoyne E. Abstract - Five new polyacetylenes named ginsenoynes A, B, C, D and E were isolated from the hexane extract of the root of Panax ginseng.These structures were determined by spectral and chemical methods.
Synthesis of panax acetylenes: Chiral syntheses of acetylpanaxydol, PQ-3 and panaxydiol
Satoh, Mitsuru,Watanabe, Mitsuo,Kawahata, Masatoshi,Mohri, Kunihiko,Yoshida, Yuki,Isobe, Kimiaki,Fujimoto, Yasuo
, p. 418 - 421 (2007/10/03)
Acetylpanaxydol (1-Ac), PQ-3 (2) and panaxydiol (3) and their optical isomers were synthesized from L-(+)-diethyl tartrate. The absolute configurations of 1-Ac, 2 and 3 were determined to be 1-Ac (3R,9R,10S), 2 (9R,10S) and 3 (3R,10S), respectively, by comparisons of their optical rotations and the NMR data of their MTPA esters with those of natural products.
Studies towards the biomimetic synthesis of ginsenoyne L; efficient synthesis of 2′-epi-ginsenoyne L
Baldwin, Jack E.,Adlington, Robert M.,Wilkinson, Peter J.,Marquez, Rodolfo,Adamo, Mauro F. A.
, p. 81 - 85 (2007/10/03)
The biomimetic synthesis of 2′-epi-gynsenyone L has been accomplished in 7 steps and in good yield through the novel use of bis-acetylenic enones as hetero Diels-Alder dienes for the mild and easy generation of dihydropyrans.
