126150-99-0

Basic information

• Product Name: 3-Piperidinecarboxylicacid,4-hydroxy-(9CI)
• Synonyms: 3-Piperidinecarboxylicacid,4-hydroxy-(9CI);4-hydroxy-3-Piperidinecarboxylic acid
• CAS NO: 126150-99-0
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• Product Categories: CARBOXYLICACID
• Mol File: 126150-99-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Piperidinecarboxylicacid,4-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinecarboxylicacid,4-hydroxy-(9CI)(126150-99-0)
• EPA Substance Registry System: 3-Piperidinecarboxylicacid,4-hydroxy-(9CI)(126150-99-0)

Safety Data

• Hazardous Substances Data: 126150-99-0(Hazardous Substances Data)

Upstream product

• 53601-94-8 4-oxo-piperidine-1,3-dicarboxylic acid diethyl ester 

Relevant articles and documents

Hydroxy- and amino-substituted piperidinecarboxylic acids as γ-aminobutyric acid agonists and uptake inhibitors

The syntheses of (3RS, 4RS)-4-hydroxypiperidine-3-carboxylic acid (4), (3RS, 5SRJ-5-hydroxypiperiden-3-carboxylic acid (20), (3RS, 4SR)-4-acetamidopiperidine-3-carboxylic acid (10), and (3RS, 5SR)-5-acetamidopiperidine-3-carboxylic acid (18), related to the specific γ-aminobutyric (GABA) uptake inhibitors (RS)-piperidine-3-carboxylic acid (nipecotic acid) and (3RS, 4SR)-4-hydroxypiperidine-3-carboxylic acid (21), are described. Furthermore, (3RS, 4SR)-3-hydroxypiperidine-4-carboxylic acid (14), related to the specific GABA agonist piperidine-4-carboxylic acid (isonipecotic acid), has been synthesized. The structures of 4, 10, 14, 18, and 20 have been established by 270-MHz 1H NMR spectroscopic analyses. The affinity of the compounds for the GABA receptors and for the neuronal (synaptosomal) GABA uptake system in vitro has been measured. Compound 14 interacts selectively with the GABA receptors but less effectively than isonipecotic acid and the cis-isomer 22. Compounds 4, 18, and 20 are inhibitors of the GABA uptake system, although much weaker than nipecotic acid and (3RS, 4SR)-4-hydroxypiperidine-3-carboxylic acid (21). Compound 10 is inactive in both test systems.

Inhibitors of GABA uptake. Syntheses and 1H NMR spectroscopic investigations of guvacine, (3RS,4SR)-4-hydroxypiperidine-3-carboxylic acid, and related compounds

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