1261557-17-8Relevant academic research and scientific papers
One-pot hydroxy group activation/carbon-carbon bond forming sequence using a Bronsted base/bronsted acid system
Devineau, Alice,Pousse, Guillaume,Taillier, Catherine,Blanchet, Jerome,Rouden, Jacques,Dalla, Vincent
supporting information; experimental part, p. 2881 - 2886 (2011/02/21)
A new sequential two-step multicatalytic strategy is presented consisting in the efficient DBU-catalysed trichloroacetimidation of an alcohol followed by a ditriflylamine (Tf2NH)-catalysed intermolecular alkylation by silicon-based nucleophiles and C-H nucleophiles. The distinct feature of the trichloroacetimidate group allows use of weaker acid catalysts such as 1,1′-bi-2-naphthol (BINOL)-derived phosphoric acid, pointing out the possible development of an enantioselective variant. This unprecedented sequential one-pot Bronsted base-Bronsted acid catalysis further expands the synthetic scope of the trichloroacetimidate group. Copyright
