1261742-22-6

Basic information

• Product Name: 2-(chloromethyl)-4-fluorobenzonitrile
• CAS NO: 1261742-22-6
• Molecular Weight: 169.586
• Mol File: 1261742-22-6.mol

Chemical Properties

• Boiling Point: 251.9±25.0 °C(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-(chloromethyl)-4-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-4-fluorobenzonitrile(1261742-22-6)
• EPA Substance Registry System: 2-(chloromethyl)-4-fluorobenzonitrile(1261742-22-6)

Safety Data

• Hazardous Substances Data: 1261742-22-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(chloromethyl)-4-fluorobenzonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(chloromethyl)-4-fluorobenzonitrile is utilized as an intermediate in the production of agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Dye and Pigment Production:
2-(chloromethyl)-4-fluorobenzonitrile is employed as a building block in the creation of dyes and pigments, leveraging its chemical properties to produce a range of colorants for various applications.
Used in Central Nervous System Research:
As a potent and selective antagonist of the Y5 receptor, 2-(chloromethyl)-4-fluorobenzonitrile is used in research and potential therapeutic development for the treatment of obesity and related conditions, providing insights into the role of the Y5 receptor in these diseases.
Used in Organic Synthesis:
2-(chloromethyl)-4-fluorobenzonitrile is used as a versatile building block in the synthesis of other organic compounds and materials, highlighting its utility in creating new chemical entities for diverse applications.

Upstream product

• 1000339-93-4 2-hydroxymethyl-4-fluorobenzonitrile 

Downstream Products

• 928201-45-0 Trelagliptin trifluoroacetate 

Relevant articles and documents

A curved geleg sandbank preparation method

The invention claims a curved geleg sandbank preparation method, using methyl urea and malonic acid diethyl ester as an initial raw material for preparing 3 - methyl - 6 - chloro uracil, while at the same time by the 2 - hydroxymethyl - 4 - pentachloro as initial material to prepare 2 - chloromethyl - 4 - pentachloro, then the 3 - methyl - 6 - chloro uracil with 2 - chloromethyl - 4 - pentachloro prepared tune geleg sandbank, the material cost is low, the preparation process is easy to control, convenient for industrial production.

Synthetic method of trelagliptin, trelagliptin synthesized through method and trelagliptin synthesis intermediate

The invention discloses a synthetic method of trelagliptin, trelagliptin synthesized through the method and a trelagliptin synthesis intermediate. The synthetic method of trelagliptin comprises the following steps: 1, taking 2-hydroxymethyl-4-fluorobenzonitrile as a starting raw material, and conducting a chlorination reaction, so that 2-chloromethyl-4-fluorobenzonitrile is obtained; 2, taking the 2-chloromethyl-4-fluorobenzonitrile as an intermediate, and conducting a condensation reaction, so that 2-[(6-chlorine-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidyl)methyl]-4-fluorobenzonitrile is obtained; 3, taking the 2-[(6-chlorine-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidyl)methyl]-4-fluorobenzonitrile as an intermediate, and conducting an ammonolysis reaction, so that trelagliptin alkali is obtained. By means of the method, use of high-toxicity copper cyanide is avoided, safety of the synthesis process is improved, environment friendliness is achieved, the formed chloro intermediate is more stable, and no irritation is caused.