1261743-74-1

Basic information

• Product Name: 4-(4-(trifluoromethyl)phenyl)-1H-indol-5-ol
• CAS NO: 1261743-74-1
• Molecular Weight: 277.246
• Mol File: 1261743-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-(trifluoromethyl)phenyl)-1H-indol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(trifluoromethyl)phenyl)-1H-indol-5-ol(1261743-74-1)
• EPA Substance Registry System: 4-(4-(trifluoromethyl)phenyl)-1H-indol-5-ol(1261743-74-1)

Safety Data

• Hazardous Substances Data: 1261743-74-1(Hazardous Substances Data)

Upstream product

• 1413810-17-9 tert-butyl furan-2-yl(2-hydroxy-4-(4-(trifluoromethyl)phenyl)but-3-yn-1-yl)carbamate 

Relevant articles and documents

5-hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition

A convergent approach provides a convenient access to synthetically and biologically useful 3,4-disubstituted 5-hydroxyindoles. The one-pot procedure uses microwave heating to initiate an intramolecular [4 + 2]-cycloaddition of an alkynol segment onto a furan followed by a fragmentation, aromatization, and N-Boc deprotection cascade. Yields range from 15 to 74%, with aromatic substituents providing better conversions. 4-Trimethylsilylated analogues undergo a 1,3-silatropic rearrangement to give the O-TMS ethers.