1261769-34-9

Basic information

• Product Name: 3-iodo-2-methoxy-6-chloropyridine
• Synonyms: 3-iodo-2-methoxy-6-chloropyridine;6-Chloro-3-iodo-2-methoxypyridine
• CAS NO: 1261769-34-9
• Molecular Formula: C₆H₅ClINO
• Molecular Weight: 269.46747
• Mol File: 1261769-34-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-iodo-2-methoxy-6-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-2-methoxy-6-chloropyridine(1261769-34-9)
• EPA Substance Registry System: 3-iodo-2-methoxy-6-chloropyridine(1261769-34-9)

Safety Data

• Hazardous Substances Data: 1261769-34-9(Hazardous Substances Data)

Upstream product

• 1072946-50-9 (6-chloro-2-methoxypyridin-3-yl)boronic acid 
• 914222-86-9 3-amino-6-chloro-2-methoxypyridine 
• 62476-56-6 3-amino-2,6-dichloropyridine 
• 17228-64-7 6-chloro-2-methoxypyridine 

Downstream Products

• 1588958-94-4 N-(5-(4-(dimethylamino)piperidin-1-yl)-6-methoxypyridin-2-yl)-9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine 
• 136353-04-3 6-chloro-2-methoxy-3-(trifluoromethyl)pyridine 

Relevant articles and documents

PYRIDAZINE DERVATIVES FOR MODULATING NUCLEIC ACID SPLICING

The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.

Computed CH acidity of biaryl compounds and their deprotonative metalation by using a mixed lithium/Zinc-TMP base

With the aim of synthesizing biaryl compounds, several aromatic iodides were prepared by the deprotonative metalation of methoxybenzenes, 3-substituted naphthalenes, isoquinoline, and methoxypyridines by using a mixed lithium/zinc-TMP (TMP=2,2,6,6-tetramethylpiperidino) base and subsequent iodolysis. The halides thus obtained, as well as commercial compounds, were cross-coupled under palladium catalysis (e.g., Suzuki coupling with 2,4-dimethoxy-5-pyrimidylboronic acid) to afford various representative biaryl compounds. Deprotometalation of the latter compounds was performed by using the lithium/zinc-TMP base and evaluated by subsequent iodolysis. The outcome of these reactions has been discussed in light of the CH acidities of these substrates, as determined in THF solution by using the DFT B3LYP method. Except for in the presence of decidedly lower pKa values, the regioselectivities of the deprotometalation reactions tend to be governed by nearby coordinating atoms rather than by site acidities. In particular, azine and diazine nitrogen atoms have been shown to be efficient in inducing the reactions with the lithium/zinc-TMP base at adjacent sites (e.g., by using 1-(2-methoxyphenyl)isoquinoline, 4-(2,5-dimethoxyphenyl)-3-methoxypyridine, or 5-(2,5-dimethoxyphenyl)-2,4-dimethoxypyrimidine as the substrate), a behavior that has already been observed upon treatment with lithium amides under kinetic conditions. Finally, the iodinated biaryl derivatives were involved in palladium-catalyzed reactions. Copyright