126181-54-2Relevant academic research and scientific papers
FLUORINE IN ENZYME CHEMISTRY: PART 1. SYNTHESIS OF DIFLUOROMETHYLENEPHOSPHONATE DERIVATIVES AS PHOSPHATE MIMICS
Chambers, R. D.,Jaouhari, R.,O'Hagan, D.
, p. 275 - 284 (2007/10/02)
Diethyl difluoromethylphosphonylcadmium bromide reacts with allyl and benzyl halides in THF to give the corresponding difluoromethylenephosphonate derivatives.The reaction with allyl bromide affords a versatile synthetic intermediate which undergoes a variety of synthetic transformations and therefore becomes a key compound in the preparation of elaborated difluoromethylenephosphonates of biological significance.
