1261833-84-4

Basic information

• Product Name: 5-(4-(trifluoromethoxy)phenyl)picolinaldehyde
• Synonyms: 5-(4-(trifluoromethoxy)phenyl)picolinaldehyde
• CAS NO: 1261833-84-4
• Molecular Weight: 267.207
• Mol File: 1261833-84-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(4-(trifluoromethoxy)phenyl)picolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-(trifluoromethoxy)phenyl)picolinaldehyde(1261833-84-4)
• EPA Substance Registry System: 5-(4-(trifluoromethoxy)phenyl)picolinaldehyde(1261833-84-4)

Safety Data

• Hazardous Substances Data: 1261833-84-4(Hazardous Substances Data)

Upstream product

• 1322001-30-8 (6-formylpyridin-3-yl)boronic acid 
• 407-14-7 1-bromo-4-(trifluoromethoxy)benzene 
• 103962-05-6 1-iodo-4-(trifluoromethoxy)benzene 
• 223463-14-7 6-bromopyridin-3-ylboronic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 

Downstream Products

• 1261451-94-8 (5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)methanol 

Relevant articles and documents

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases disorders or symptoms thereof mediated by such metalloenzymes.

ANTIFUNGAL COMPOUND PROCESS

The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 or la and substituted derivatives thereof.