1261849-80-2

Upstream product

• 269738-15-0 ethyl 2-amino-3-chlorobenzoate 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 1211594-32-9 3-chloro-2-cyanobenzoic acid methyl ester 
• 77820-58-7 methyl 3-chloroanthranilate 
• 1254073-93-2 3-chloro-2-cyanobenzoic acid 
• 127510-92-3 3-chloro-2-cyano-benzoic acid ethyl ester 

Relevant academic research and scientific papers

UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described in the description. The compound can block interaction between the PD-1/PD-L1 signalling pathways. The compound of the present invention can be used for treating or preventing diseases related to the signalling pathways, such as cancer, autoimmune disease, chronic infectious disease, and other diseases.

Compounds Useful as Immunomodulators

The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

COMPOUNDS USEFUL AS IMMUNOMODULATORS

Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.