126193-27-9

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-2-PHENYLAMINO-THIAZOLE-5-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceuticals for its wide range of biological activities and potential therapeutic applications.
Used in Agrochemical Industry:
4-CHLORO-2-PHENYLAMINO-THIAZOLE-5-CARBALDEHYDE is used as a building block in the development of agrochemicals, contributing to the creation of effective products for agricultural use.
Used in Medicinal Chemistry Research:
4-CHLORO-2-PHENYLAMINO-THIAZOLE-5-CARBALDEHYDE is used as a research compound for studying its anti-cancer and anti-inflammatory properties, as well as its role as a potent inhibitor of thioredoxin reductase, which is crucial in redox signaling and antioxidant defense.

InChI:InChI=1/C10H7ClN2OS/c11-9-8(6-14)15-10(13-9)12-7-4-2-1-3-5-7/h1-6H,(H,12,13)

Upstream product

• 17823-27-7 2-phenylaminothiazol-4-one 
• 10025-87-3 trichlorophosphate 
• 55620-29-6 2-phenylaminothiazolidin-4-one 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 126193-29-1 5-phenylaminopyrazolo<4.3-d>thiazole 
• 126193-30-4 5-phenylaminothiazolo<5,4-d>isoxazole 
• 126193-37-1 N,N'-bis(4-chloro-2-phenyliminothiazol-5-ylmethylene)azine 
• 126193-34-8 N,N'-bis(4-chloro-2-phenyliminothiazol-5-ylmethylene)ethylenediamine 
• 126193-36-0 N,N'-bis(4-chloro-2-phenyliminothiazol-5-ylmethylene)-p-phenylenediamine 
• 126193-32-6 5-hydroxy-2-phenylaminothiazolo<4.5-d>pyrimidine 
• 126193-31-5 5-mercapto-2-phenylaminothiazolo<4,5-d>pyrimidine 
• 126193-28-0 1-phenyl-5-phenylaminopyrazolo<4,3-d>thiazole 
• 126193-35-9 N,N'-bis(4-chloro-2-phenyliminothiazol-5-ylmethylene)-o-phenylenediamine 
• 126193-33-7 2-phenylimino-thiazo<4.5-e><1.4>benzodiazepine 

Relevant academic research and scientific papers

Use of 2,4-diaminothiazole derivatives

2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.

Studies on Vilsmeier-Haack reaction: A versatile new synthesis of 4-chloro-2-phenylaminothiazole-5-carboxaldehyde and related fused heterocyclic compounds and heterocyclic Schiff's bases

2-Phenyliminothiazolidin-4-one (I) on formylation using Vilsmeier-Haack reagent (VR) yields a versatile intermediate 4-chloro-2-phenylaminothiazole-5-carboxaldehyde (II) which reacts with various amines to give heterocyclic compounds (III-VIII) and schiff