1261999-27-2Relevant academic research and scientific papers
Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore
Nishio, Yukihiro,Kimura, Hidenori,Tosaki, Shinya,Sugaru, Eiji,Sakai, Mutsuko,Horiguchi, Masakuni,Masui, Yumi,Ono, Michiko,Nakagawa, Tsutomu,Nakahira, Hiroyuki
scheme or table, p. 7246 - 7249 (2011/01/03)
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioavailability and PK/PD profile in ZF-rat.
