1262018-03-0Relevant articles and documents
Synthesis of α-methyl ketones by a selective, iridium-catalyzed cyclopropanol ring-opening reaction
Ziegler, Daniel T.,Steffens, Andrew M.,Funk, Timothy W.
, p. 6726 - 6729 (2010)
A mild method for synthesizing α-methyl ketones from substituted cyclopropanols is reported. This process, catalyzed by [CpIrCl2] 2, cleaves cyclopropanol rings regioselectively and more efficiently than the other conditions examined. While tertiary cyclopropanols afford α-methyl ketones, secondary cyclopropanols and cyclopropyl silyl ethers are less reactive and yield other isomerization products.
