1262033-18-0Relevant articles and documents
3,5-Disubstituted pyranone analogues of highly antifungally active furanones: Conversion of biological effect from antifungal to cytostatic
Schiller, Radan,Tichotová, Lucie,Pavlík, Jan,Buchta, Vladimír,Melichar, Bohuslav,Votruba, Ivan,Kune?, Ji?í,?pulák, Marcel,Pour, Milan
scheme or table, p. 7358 - 7360 (2011/01/12)
A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells.