1262041-49-5 Usage
Description
ASK1-IN-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), a protein kinase that plays a significant role in the cellular response to stress, such as oxidative stress and endoplasmic reticulum stress, and is involved in the activation of apoptotic cell death. ASK1's aberrant activation has been linked to various pathological conditions, including neurodegenerative disorders, cardiovascular diseases, and cancer.
Uses
Used in Pharmaceutical Industry:
ASK1-IN-1 is used as a therapeutic agent for the treatment of neurodegenerative disorders, cardiovascular diseases, and cancer. Its ability to inhibit ASK1 could potentially help in managing these conditions by reducing the aberrant activation of the kinase and the associated apoptotic cell death.
Used in Research Applications:
ASK1-IN-1 is used as a research tool for studying the role of ASK1 in cellular stress response and apoptosis. It aids in understanding the molecular mechanisms underlying the activation of ASK1 and its implications in various pathological conditions.
However, it is important to note that the effects and safety of ASK1-IN-1 in humans are not completely understood, and further research is needed to fully explore its potential applications and therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 1262041-49-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,0,4 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1262041-49:
(9*1)+(8*2)+(7*6)+(6*2)+(5*0)+(4*4)+(3*1)+(2*4)+(1*9)=115
115 % 10 = 5
So 1262041-49-5 is a valid CAS Registry Number.
1262041-49-5Relevant articles and documents
APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
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Page/Page column 52, (2011/02/15)
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. T
