1262043-91-3

Upstream product

• 36052-26-3 methyl 6-aminopyridine-2-carboxylate 
• 765-30-0 Cyclopropylamine 
• 1448427-98-2 C₁₂H₁₈N₆O 
• 5584-18-9 6-aminopyridine-2-carbohydrazide 
• 1262043-89-9 benzyl (6-(hydrazinecarbonyl)pyridin-2-yl)carbamate 
• 1262043-88-8 methyl 6-(benzyloxycarbonylamino)-pyridine-2-carboxylate 
• 1262043-90-2 benzyl (6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)carbamate 

Relevant academic research and scientific papers

FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS

Described herein are ASK1 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with ASK1 activity.

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS

The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. T