1262044-52-9Relevant academic research and scientific papers
Thermoregulated aqueous biphasic catalysis of sonogashira reactions
Zhao, Xiaohua,Liu, Xiang,Lu, Ming
, p. 1614 - 1617 (2015/10/20)
A water-based thermoregulated system for Pd-catalyzed Sonogashira reactions is presented, which allows for not only a highly efficient homogeneous catalytic reaction, but also an easy separation/recovery of the catalyst. The novel catalytic system exhibits high efficiency and excellent reusability. In addition, the Sonogashira reactions are performed with Pd(OAc)2 without a copper co-catalyst.
Cross-coupling reactions catalyzed by an N-heterocyclic carbene-Pd(ii) complex under aerobic and CuI-free conditions
Lu, Hongfei,Wang, Lin,Yang, Feifei,Wu, Runze,Shen, Wei
, p. 30447 - 30452 (2014/08/05)
A Pd-complex, (Cat. 3), has been successfully employed as a highly efficient and recyclable catalyst for the Sonogashira and Heck reactions of aryl bromides with various terminal acetylenes and olefins. The catalytic reactions proceed with excellent yields with a low catalyst loading (1.0 mol%) under aerobic and CuI-free conditions. A plausible mechanism has also been proposed for the reaction. the Partner Organisations 2014.
Palladacycle-catalyzed decarboxylative coupling of alkynyl carboxylic acids with aryl chlorides under air
Li, Xi'Ang,Yang, Fan,Wu, Yangjie
, p. 4543 - 4550 (2013/06/05)
A highly efficient and practical protocol for palladacycle-catalyzed decarboxylative coupling of alkynyl carboxylic acids with aryl chlorides was developed. The reaction could proceed smoothly in air within 3 h under optimized reaction conditions (1 mol % of palladacycle, 4 mol % of Xphos, 2.0 equiv of K2CO3 in xylene/H2O), affording the corresponding internal alkynes in mostly good to excellent yields. Remarkably, this result represents the first successful examples of this type of decarboxylative cross-coupling using electron-poor, electron-neutral and even inactive sterically hindered electron-rich aryl chlorides as the starting materials.
Copper-catalyzed decarboxylative cross-coupling of alkynyl carboxylic acids with aryl halides
Zhao, Dongbing,Gao, Chao,Su, Xiaoyu,He, Yunqing,You, Jingsong,Xue, Ying
supporting information; experimental part, p. 9049 - 9051 (2011/02/17)
The copper-catalyzed decarboxylative reactions of alkynyl carboxylic acids with aryl halides were performed under relatively mild reaction conditions. Benzofurans could be further prepared smoothly by a one-pot domino protocol on the basis of decarboxylative cross-coupling of 2-iodophenol.
