1262050-02-1Relevant articles and documents
Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1- yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2- one derivatives with antiarrhythmic and antihypertensive activity
Kulig, Katarzyna,Sapa, Jacek,Nowaczyk, Alicja,Filipek, Barbara,Malawska, Barbara
experimental part, p. 649 - 662 (2010/08/05)
A series of novel phenylpiperazine and phenylpiperidine derivatives bearing a 3,3-disubstituted pyrrolidin-2-one fragment were synthesized and evaluated for their binding affinity for α1-adrenoceptors (ARs) and for their antiarrhythmic and anti