1262053-75-7Relevant academic research and scientific papers
Addition of C-nucleophiles to 5-phenylpyrimidin-2(1H)-ones and 6-phenyl-1,2,4-triazin-3(2H)-one
Egorov, Ilya N.,Tseitler, Tatyana A.,Zyryanov, Grigory V.,Rusinov, Vladimir L.,Chupakhin, Oleg N.
experimental part, p. 312 - 323 (2011/12/15)
Addition reactions of C-nucleophiles to the C=N bond of 5-phenyl- and 1-methyl-5-phenylpyrimidin-2(1H)-ones 1a,b and 6-phenyl-1,2,4-triazin-3(2H)-one 2 were investigated. 1a,b and 2 furnished addition products with indoles; 1a also added N-methylpyrrole. Only 2 added thiophene and methyl ketones, and reacted with alkyl halides and acetone forming products resulting both from alkylation and from addition of acetone at positions 2 and 5, respectively.
Asymmetric induction in the reactions of azinones with C-nucleophiles
Chupakhin,Egorov,Rusinov,Slepukhin
experimental part, p. 991 - 1001 (2011/02/27)
Effect of acylating agents on the course of addition of C-nucleophiles to 1,2,4- and 1,3,5-triazinones, as well as to quinoxalin-2(1H)-one, was studied. A series of new azinone derivatives was obtained. A method for the preparation of diastereomerically pure addition products of indoles to 1,2,4-triazinones and quinoxalin-2(1H)-one in the presence of N-Ts-L-amino acid acyl chlorides was suggested.
