126208-87-5 Usage
General Description
"(17beta)-17-(hydroxymethyl)estra-4,14-dien-3-one" is a synthetic derivative of the natural hormone estradiol. It is commonly known as tibolone and is used as a hormone replacement therapy in postmenopausal women to relieve symptoms of menopause such as hot flashes and vaginal dryness. Tibolone has estrogenic, progestogenic, and androgenic effects and is taken orally in the form of tablets. It works by acting on estrogen, progesterone, and androgen receptors in the body, helping to restore hormonal balance and alleviate menopausal symptoms. Tibolone is also being investigated for its potential use in the treatment of other conditions such as osteoporosis.
Check Digit Verification of cas no
The CAS Registry Mumber 126208-87-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,2,0 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 126208-87:
(8*1)+(7*2)+(6*6)+(5*2)+(4*0)+(3*8)+(2*8)+(1*7)=115
115 % 10 = 5
So 126208-87-5 is a valid CAS Registry Number.
126208-87-5Relevant articles and documents
Preparation and epoxidation of 8(14)- and 14,15-unsaturated 17β-hydroxymethylestranes
Schubert, G.,Schoenecker, B.,Ponsold, K.,Tresselt, D.
, p. 310 - 311 (2007/10/02)
17β-Hydroxymethyl-estra-4,8(14)-dien-3-one(3) and 17β-hydroxymethyl-estra-4,14-dien-3-one(4) were obtained by transformation of the 3-ethylene dithioketal 2a with methyliodide in acetonitrile.Epoxidation of 3 and 4 with m-chloroperbenzoic acid in chloroform gave the 8α,14α-epoxide 5 and the 14,15-epoxides 6 and 7, respectively.The structure of the compounds were elucidated by UV, IR, NMR and mass spectroscopy.
