1262097-80-2Relevant academic research and scientific papers
Facile synthesis of symmetrical 3,3-diarylacrylates by a Heck-Matsuda reaction: An expedient route to biologically active indanones
Taylor, Jason G.,Ribeiro, Rodrigo Da Silva,Correia, Carlos Roque D.
experimental part, p. 3861 - 3864 (2011/08/06)
A simple and straightforward synthesis of symmetrical 3,3-diarylacrylates based on a Heck-Matsuda reaction of arenediazonium salts bearing electron-donating groups with methylacrylates is described. The reaction employs Pd(OAc)2 as catalyst and goes to completion within 1 h affording the corresponding unsaturated diaryl esters in good to high yields. This method permitted the expeditious and efficient synthesis of the anticancer 3-arylindanone 5 in two operative steps in 43% overall yield.
Pd-catalyzed decarboxylative arylation of silyl enol ester sp3 β-C-H bond under aerobic conditions
Fu, Zhengjiang,Huang, Shijun,Kan, Jian,Su, Weiping,Hong, Maochun
supporting information; experimental part, p. 11317 - 11321 (2011/02/16)
Pd-catalyzed aerobic oxidative coupling of various benzoic acids with silyl enol esters proceeds via a combination of decarboxylation with sp3 β-C-H bond activation to give Heck-type products. Mechanistic studies reveal this coupling involves in situ generation of olefin from aerobic oxidation of silyl enolate, followed by decarboxylative Heck coupling.
