1262147-53-4Relevant academic research and scientific papers
Zn(II)ferrocenylthiosemicarbazones: DNA binding and nuclease activity
Rajamuthy, Vikneswaran,Teoh, Siang Guan,Majid, Amin Malik Shah Abdul,Yeap, Chin Sing,Fun, Hoong-Kun,Ng, Chew Hee,Ng, Seik Weng
, p. 149 - 156 (2013)
A series of Zn(II) ferrocenylthiosemicarbazones complexes derived from thiosemicarbazide and 4-methyl-, 4-ethyl-, and 4-phenyl-3-thiosemicarbazide were evaluated for their DNA binding propensity and chemical nuclease activity. The equilibrium binding constants, Kb, of the complexes for binding with calf thymus DNA (CT DNA) were in the range of 0.68 × 103 to 2.8 × 104 M-1. The complexes do not intercalate into the nucleobases of CT DNA, as evident from viscosity measurements. They exhibit efficient nuclease activity in the absence of an activating agent and cleave supercoiled DNA into nicked and linear circular forms of DNA at very low concentrations. Copyright Taylor & Francis Group, LLC.
