1262202-51-6

Basic information

• Product Name: C₂₀H₁₈N₂O₃
• CAS NO: 1262202-51-6
• Molecular Weight: 334.375
• Mol File: 1262202-51-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈N₂O₃(1262202-51-6)
• EPA Substance Registry System: C₂₀H₁₈N₂O₃(1262202-51-6)

Safety Data

• Hazardous Substances Data: 1262202-51-6(Hazardous Substances Data)

Upstream product

• 13599-12-7 ethyl 3-phenyl-1H-pyrazole-5-carboxylate 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

Synthesis, crystal structure and biological evaluation of novel 2-(5-(hydroxymethyl)-3-phenyl-1H-pyrazol-1-yl)-1-phenylethanol derivatives

A series of novel 2-(5-(hydroxymethyl)-3-phenyl-1H-pyrazol-1-yl)-1- phenylethanol derivatives (4) was synthesized from ethyl 1-(2-oxo-2-phenylethyl) -3-phenyl-1H-pyrazole-5-carboxylate derivatives (3) and characterized by means of IR, 1H NMR, HRMS and X-ray crystal diffraction. Structures of 4a, 4d, 4e and 4f were also determined by 13C NMR. Isomeric intermediates, 3a and 5a, were unambiguously confirmed by X-ray crystal structure analysis and successfully differentiated with 1H NMR chemical shifts of methylene bonded to pyrazole ring. Preliminary biological evaluation showed that compounds 4d and 4e could suppress A549 lung cancer cell growth through cell cycle arrest and autophagy.