1262219-87-3Relevant academic research and scientific papers
Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells
Andreoli, Mirko,Persico, Marco,Kumar, Ajay,Orteca, Nausicaa,Kumar, Vineet,Pepe, Antonella,Mahalingam, Sakkarapalayam,Alegria, Antonio E.,Petrella, Lella,Sevciunaite, Laima,Camperchioli, Alessia,Mariani, Marisa,Di Dato, Antonio,Novellino, Ettore,Scambia, Giovanni,Malhotra, Sanjay V.,Ferlini, Cristiano,Fattorusso, Caterina
, p. 7916 - 7932 (2014/12/10)
Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing the incorporation of the GBP1 GTPase into microtubules. Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a sig
Synthesis of novel functionalized 4-aza-2,3-didehydropodophyllotoxin derivatives with potential antitumor activity
Kumar, Ajay,Alegria, Antonio E.
experimental part, p. 1275 - 1282 (2011/02/21)
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.
