126222-79-5

Upstream product

• 203806-62-6 (2R,3S)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-triisopropylsilanyloxy-butyric acid methyl ester 

Downstream Products

• 117997-58-7 tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 
• 143122-12-7 (4S,5R)-3-(tert-butoxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyloxazolidine-5-methanol 

Relevant academic research and scientific papers

New approaches to the asymmetric synthesis of dipeptide isosteres via β-Lactam Synthon Method

New and efficient synthetic routes to dipeptide isosteres with high enantiomeric purity, e.g., hydroxyethylene, dihydroxyethylene and hydroxyethylamine isosteres, have been developed via oxiranes 6 and formyloxazolines 13 derived from N-t-Boc-β-lactams 4.

AMINO ACID DERIVATIVES

The compounds of the formula STR1 wherein A, R 1, R. sup.2, R. sup.3, R 4, R 5 and R 6 are as set forth above, are described. The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.