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2-(1-cyclohexylpiperidin-4-yl)-6-fluoro-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1262396-20-2

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1262396-20-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1262396-20-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,3,9 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1262396-20:
(9*1)+(8*2)+(7*6)+(6*2)+(5*3)+(4*9)+(3*6)+(2*2)+(1*0)=152
152 % 10 = 2
So 1262396-20-2 is a valid CAS Registry Number.

1262396-20-2Relevant academic research and scientific papers

Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515

Papeo, Gianluca,Orsini, Paolo,Avanzi, Nilla R.,Borghi, Daniela,Casale, Elena,Ciomei, Marina,Cirla, Alessandra,Desperati, Viviana,Donati, Daniele,Felder, Eduard R.,Galvani, Arturo,Guanci, Marco,Isacchi, Antonella,Posteri, Helena,Rainoldi, Sonia,Riccardi-Sirtori, Federico,Scolaro, Alessandra,Montagnoli, Alessia

supporting information, p. 534 - 538 (2019/03/26)

Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD+ to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well established targe

3-0X0-2, 3, -DIHYDRO-LH-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION

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Page/Page column 38, (2011/02/24)

There are provided substituted 3 -oxo - 2, 3 -dihydro- 1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

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