1262414-96-9

Basic information

• Product Name: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE
• Synonyms: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE;2-Fluoro-4-methoxy-1-isopropylbenzene;2-fluoro-isopropyl-4-Methoxybenzene;Benzene, 2-fluoro-4-Methoxy-1-(1-Methylethyl)-;EOS-61122
• CAS NO: 1262414-96-9
• Molecular Formula: C10H13FO
• Molecular Weight: 168.21
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 1262414-96-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 190℃
• Flash Point: 67℃
• Appearance: /
• Density: 1.002
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE(1262414-96-9)
• EPA Substance Registry System: 2-(2'-FLUORO-4'-METHOXYPHENYL)PROPANE(1262414-96-9)

Safety Data

• Hazardous Substances Data: 1262414-96-9(Hazardous Substances Data)

Usage

General Description

2-(2'-Fluoro-4'-methoxyphenyl)propane is a chemical compound with the molecular formula C10H13F that belongs to the class of organic compounds known as phenylpropanes. This chemical is a colorless liquid with a faint sweet odor and is used in the production of various industrial and consumer products. It is also utilized in pharmaceuticals and as a solvent in the manufacturing of other chemicals. Its properties and applications make it a versatile chemical in the fields of chemistry, pharmaceuticals, and industry.

Upstream product

• 458-50-4 1-bromo-2-fluoro-4-methoxybenzene 
• 38111-45-4 iso-propylzinc chloride 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 96826-25-4 2-(2-fluoro-4-methoxyphenyl)-2-isopropanol 
• 875446-55-2 2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene 

Downstream Products

• 875551-28-3 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl 
• 1312671-75-2 5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 875548-98-4 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl 
• 1312671-76-3 (+)-(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,5-dimethyl-1,3-oxazolidin-2-one 
• 875549-49-8 (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 1312671-81-0 (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 

Relevant articles and documents

Carbon Dioxide-Mediated C(sp2)-H Arylation of Primary and Secondary Benzylamines

C-C bond formation by transition metal-catalyzed C-H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of ortho-arylbenzylamines, however, effective ortho-C-C bond formation of free primary and secondary benzylamines using PdII remains an outstanding challenge. Presented herein is a new strategy for constructing ortho-arylated primary and secondary benzylamines mediated by carbon dioxide (CO2). The use of CO2 with Pd is critical to allowing this transformation to proceed under relatively mild conditions, and mechanistic studies indicate that it (CO2) is directly involved in the rate-determining step. Furthermore, the milder temperatures furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, an interesting chelate effect is shown to facilitate selective monoarylation.

Method of preparing ansai qu Pi intermediate

The invention relates to a method for preparing a compound fluoro-4-methoxy-1-isopropyl benzene shown as a formula (II)(refer to the Specification). The method comprises the following steps: dissolving a compound 2-(2-fluoro-4-methoxy phenyl) propane-2-ol

PROCESS FOR A CETP INHIBITOR

An efficient process is disclosed for producing the compound of formula I, which is the CETP inhibitor anacetrapib, which raises HDL-cholesterol and reduces LDL-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis:.