1262418-84-7Relevant articles and documents
Synthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/β-catenin pathway
Lee, Jee-Hyun,Kim, Min-Ah,Park, Seoyoung,Cho, Soo-Hyun,Yun, Eunju,O, Yu-Seok,Kim, Jiseon,Goo, Ja-Il,Yun, Mi-Young,Choi, Yongseok,Oh, Sangtaek,Song, Gyu-Yong
supporting information, p. 3529 - 3532 (2016/07/21)
We synthesized (+)-decursin derivatives substituted with cinnamoyl- and phenyl propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound 8b, in which a
Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
Lee, Kyeong,Lee, Jee-Hyun,Boovanahalli, Shanthaveerappa K.,Choi, Yongseok,Choo, Soo-Jin,Yoo, Ick-Dong,Kim, Dong Hee,Yun, Mi Young,Lee, Gye Won,Song, Gyu-Yong
experimental part, p. 5567 - 5575 (2011/02/22)
We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity.
