1262445-63-5Relevant academic research and scientific papers
Synthesis and biological evaluation of conformationally restricted σ1 receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold
Sunnam, Sunil K.,Schepmann, Dirk,Rack, Elisabeth,Froehlich, Roland,Korpis, Katharina,Bednarski, Patrick J.,Wuensch, Bernhard
, p. 5525 - 5540 (2010)
The key step in the synthesis of the 7,9-diazabicyclo[4.2.2]decane system was a modified Dieckmann condensation of piperazinebutyrate 11, which makes use of trapping the first cyclized intermediate with TMS-Cl. Reduction of the bicyclic ketone 14 with LiB
