1262487-87-5

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 18940-21-1 5,5-dimethyl-3-(phenylamino)cyclohex-2-en-1-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 126-81-8 dimedone 

Relevant academic research and scientific papers

Novel benzo[b]xanthene derivatives: Bismuth(III) triflate-catalyzed one-pot synthesis, characterization, and acetylcholinesterase, glutathione S-transferase, and butyrylcholinesterase inhibitory properties

In this study, 3,4-dihydro-12-aryl-1H-benzo[b]xanthene-1,6,11-(2H,12H)trione compounds were obtained through one-pot condensation of various substituted aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone, and dimedone in the presence of Bi(OTf)3 as a green and reusable catalyst. The structural characterization of these novel substituted benzo[b]xanthenes was performed by spectroscopic methods, and their inhibitory actions against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and glutathione S-transferase (GST) were investigated. GST is an enzyme responsible for removing toxic molecules during Phase II reactions in the detoxification mechanism. The AChE and BChE enzymes, which are called cholinesterases, are among the enzymes that occur especially during dementia such as brain damage or Alzheimer's disease. Inhibition effects of the benzo[b]xanthene derivatives on AChE, BChE, and GST were found at the millimolar level. The best inhibitor for GST is compound 4a (31.18 ± 6.13 mM), for AChE, it is compound 4d (28.16 ± 3.46 mM), and for BChE, it is compound 4f (36.24 ± 3.19 mM). Compound 4a inhibited the dimerization of GST subunits, and compounds 4d and 4f directly inhibited the catalytic activity by interacting with the catalytic active site or a related site of the AChE and BChE enzymes, respectively.

An Efficient Strategy for the Synthesis of Naphtho[2,3- b ][1,6]naphthyridines Promoted by Acetic Acid

A three-component domino reaction for the synthesis of naphtho[2,3- b ][1,6]naphthyridine derivatives has been established. Such strategy exhibited excellent substrate scope including various enaminones and aldehydes that afforded a series of multifunctionalized naphtho[2,3- b ][1,6]naphthyridine derivatives with 70-86% yields. The advantages of bond-forming efficiency, accessibility of starting materials, and water as sole byproducts provide invaluable access to biological 1,6-naphthyridines.

Application of cobalt phthalocyanine as a nanostructured catalyst in the synthesis of biological henna-based compounds

The present investigation describes synthesis of a good range of henna-based compounds in the presence of novel nano cobalt phthalocyanine like molten salt (tetra-2,3-pyridiniumporphyrazinato cobalt tribromomethanide) [Co (TPPABr)]CBr3 as an efficient, recyclable and thermally stable heterogeneous catalyst.

Br?nsted acidic ionic liquids catalyzed the preparation of 13-aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones and 3,4-dihydro-1H-benzo[b]xanthene-1,6,11(2H,12H)-triones

An environmentally green method for the synthesis of 13-aryl-5H-dibenzo[b, i]xanthene-5,7,12,14(13H)-tetraone and 3,4-dihydro-1H-benzo[b]xanthene-1,6, 11(2H,12H)-trione derivatives using Br?nsted acidic ionic liquids, 3-methyl-1-sulfonic acid imidazolium chloride, 1-H-3-methyl-imidazolium hydrogensulfate, triethylamine-bonded sulfonic acid, and triethylammonium hydrogensulfate as reusable catalysts under thermal solvent-free conditions is described.

Phosphoric acid supported on alumina (H3PO4/Al 2O3) as an efficient and reusable catalyst for the one-pot synthesis of benzoxanthene pigments

Phosphoric acid supported on alumina (H3PO4/Al 2O3) is an efficient catalyst for the catalytic multi-component condensation reaction and a wide variety of syntheses of benzoxanthene pigments in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction, and simple experimental and work-up procedures.

Polystyrene-supported GaCl3 as a highly efficient and reusable heterogeneous Lewis acid catalyst for the three-component synthesis of benzoxanthene derivatives

Naphthoquinone-based xanthenes, specifically 14-aryl-13H-dibenzo[a,i] xanthene-8,13(14H)-diones and 12-aryl-2,3,4,12-tetrahydro-1H-benzo[b]xanthene-1, 6,11-triones, were obtained in good to excellent yields by a simple, mild, and efficient three-component coupling procedure utilizing polystyrene-supported gallium trichloride as a highly active and eco-friendly heterogeneous Lewis acid catalyst. This reaction was also extended to the preparation of 14-aryl-2-hydroxy-13H-dibenzo[a,i]xanthene-8,13(14H)-diones. The experimental and work-up procedure is very simple and the catalyst can be easily separated from the reaction mixture and reused several times in subsequent reactions.

Synthesis of benzoxanthene derivatives using Bronsted acidic ionic liquids (BAILs), 2-pyrrolidonium hydrogen sulfate and (4-sulfobutyl)tris(4- sulfophenyl)phosphonium hydrogen sulfate

Bronsted acidic ionic liquids (BAILs), 2-pyrrolidonium hydrogen sulfate and (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate are found to be efficient catalysts for synthesis of 14-aryl-14H-dibenzo[a,i] xanthene-8,13-dione, 3,4-dihydro-1H-benzo[b]xanthene-1,6,11(2H,12H)-trione, and aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraone derivatives.

An efficient three-component synthesis of benzoxanthenes in water

(Chemical Equation Presented) A clean, one-pot and three-component synthesis of new dibenzo[a,i]xanthene-diones derivatives by cyclo-condensation reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and dimedone or 2-naphthol in aqueous media is reported.