1262519-09-4

Basic information

• Product Name: C₁₂H₈FNO₃
• CAS NO: 1262519-09-4
• Molecular Weight: 233.199
• Mol File: 1262519-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₈FNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₈FNO₃(1262519-09-4)
• EPA Substance Registry System: C₁₂H₈FNO₃(1262519-09-4)

Safety Data

• Hazardous Substances Data: 1262519-09-4(Hazardous Substances Data)

Upstream product

• 931-34-0 5-bromo-1H-pyrrole-2-carbaxaldehyde 
• 1072952-09-0 3-borono-2-fluorobenzoic acid 

Relevant articles and documents

Design, synthesis, and biological activity of novel 5-((arylfuran/1 H -pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl) thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41

On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3- (trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds 12a-o effectively inhibited infection by both laboratory-adapted and primary HIV-1 strains and blocked HIV-1 mediated cell-cell fusion and gp41 six-helix bundle formation. Molecular docking analyses on two highly active inhibitors, 12b, containing a carboxylic acid group, and 12m, containing a tetrazole group, indicated that they both fit snugly into the hydrophobic cavity of HIV-1 gp41 from which each has important ionic interactions with lysine 574 (K574). By contrast, molecular docking of 12i, a less active compound containing a pyrrole instead of a furan ring, indicated a completely different orientation from 12b and 12m and missed critical interactions.