1262544-91-1

Upstream product

• 5397-76-2 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone 
• 62-23-7 4-nitro-benzoic acid 
• 87486-34-8 3,5-dibromo-1-methyl-1,2-dihydropyrazin-2-one 
• 51207-86-4 (4-amino-phenyl)-morpholin-4-yl-methanone 

Downstream Products

• 1262544-87-5 5-(3-amino-2-methylphenyl)-1-methyl-3-(4-(morpholine-4-carbonyl)phenylamino)pyrazin-2(1H)-one 
• 1622173-21-0 5-(1-acetylindolin-5-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1622173-11-8 N-(3,4-dimethylphenyl)-4-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)indoline-1-carboxamide 
• 1622172-99-9 5-(1-(3,4-dimethoxybenzoyl)indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1622172-89-7 5-(1-(2,4-dimethoxybenzoyl)-1H-indol-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1622173-54-9 5-(indolin-4-yl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1620088-93-8 5-(3-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1620089-47-5 5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1620089-57-7 5-(3-(4-ethyl-3-methyl-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1620090-01-8 1-methyl-5-(2-methyl-3-(2-oxoimidazolidin-1-yl)phenyl)-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one 
• 1361940-86-4 5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one 
• 1361940-85-3 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid 
• 1361940-83-1 ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate 

Relevant academic research and scientific papers

SUBSTITUTED 2-PYRAZINONE DERIVATIVES AS KINASE INHIBITORS

The present invention provides novel substituted 2-pyrazinone derivatives of formula (1) as protein kinase inhibitors, in which R1; R2, R3, R4, R5, R6, R7 and 'p' have the meanin

N-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS KINASE INHIBITORS

The present invention provides N-substituted novel heterocyclic derivatives of formula (I) as protein kinase inhibitors, in which R1, R2 and 'n' have the same meanings given in the specification, and pharmaceutically acceptable salts

PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF

Pyridone and pyrazinone compounds of Formula (I) including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.