1262587-75-6

Upstream product

• 931-49-7 1-ethenylcyclohexene 
• 10031-82-0 4-ethoxybenzaldehyde 

Downstream Products

• 1316845-41-6 2-benzyl-3-cyclohex-1-enyl-4-iodo-5-(4-ethoxyphenyl)-5,10-dihydroazepino[3,4-b]indol-1(2H)-one 
• 1316845-47-2 2-cyclopentyl-3-cyclohex-1-enyl-4-iodo-5-(4-ethoxyphenyl)-5,10-dihydroazepino[3,4-b]indol-1(2H)-one 
• 1316845-44-9 2-tert-butyl-3-cyclohex-1-enyl-4-iodo-5-(4-ethoxyphenyl)-5,10-dihydroazepino[3,4-b]indol-1(2H)-one 

Relevant academic research and scientific papers

Synthesis of iodo-indoloazepinones in an iodine-mediated three-component domino reaction via a regioselective 7-endo-dig iodo-cyclization pathway ±

An efficient and rapid synthetic strategy for the naturally occurring indoloazepinone scaffold via a three-component reaction of indole-2- carboxamides, 1,3-disubstituted propargyl alcohols, and I2 is described. The strategy involves a C-H functionalization-alkyne activation-intramolecular hydroamidation-deprotonation domino sequence. The salient feature of this sequence is regioselective electrophilic 7-endo-dig iodo-cyclization during the intramolecular hydroamidation to afford a seven-membered azepinone ring annulated to the indole.

Three component tandem reactions involving protected 2-amino indoles, disubstituted propargyl alcohols, and I2/ICl: Iodo-reactant controlled synthesis of dihydro-α-carbolines and α-carbolines via iodo-cyclization/iodo-cycloelimination

Two simple, highly efficient three component tandem reactions for the synthesis of diversified Na Nb di-carbamate-4,9-dihydro-3- iodo-α-carbolines and Na-carbamate-3-iodo-α-carbolines have been described. The strategy invo