126260-53-5

Basic information

• Product Name: 2-{2-[5-Bromo-7-(toluene-4-sulfonyloxy)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 126260-53-5
• Molecular Weight: 606.538
• Mol File: 126260-53-5.mol

Chemical Properties

• CAS DataBase Reference: 2-{2-[5-Bromo-7-(toluene-4-sulfonyloxy)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2-[5-Bromo-7-(toluene-4-sulfonyloxy)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester(126260-53-5)
• EPA Substance Registry System: 2-{2-[5-Bromo-7-(toluene-4-sulfonyloxy)-1H-indol-3-yl]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid tert-butyl ester(126260-53-5)

Safety Data

• Hazardous Substances Data: 126260-53-5(Hazardous Substances Data)

Upstream product

• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 201684-57-3 5-bromo-7-(p-toluenesulfonyloxy)tryptamine 
• 201684-59-5 5-bromo-7-(p-toluenesulfonyloxy)indole-2-carboxylic acid 
• 126260-59-1 (E)-5-bromo-3-nitrovinyl-7-(p-toluenesulfonyloxy)indole 
• 126260-58-0 ethyl 5-bromo-7-tosyloxyindole-2-carboxylate 
• 15761-39-4 N^α-(tert-butyloxycarbonyl)-L-proline 
• 201684-34-6 Toluene-4-sulfonic acid 5-bromo-3-formyl-1H-indol-7-yl ester 
• 201684-32-4 5-bromo-7-(p-toluenesulfonyloxy)indole 

Downstream Products

• 102673-53-0 6-Bromo-1-(4,5-dihydro-3H-pyrrol-2-yl)-9H-β-carbolin-8-ol 
• 126260-54-6 Toluene-4-sulfonic acid 6-bromo-1-(4,5-dihydro-3H-pyrrol-2-yl)-9H-β-carbolin-8-yl ester 
• 201684-38-0 Toluene-4-sulfonic acid 6-bromo-1-(4,5-dihydro-3H-pyrrol-2-yl)-4,9-dihydro-3H-β-carbolin-8-yl ester 

Relevant articles and documents

Fischer indolization of 2-sulfonyloxyphenylhydrazones: A new and practical approach for preparing 7-oxygenated indoles and application to the first synthesis of eudistomidin-A. (Fischer indolization and its related compounds. Part 28)

An efficient method for synthesis of 7-oxygenated indoles was established by Fischer indolization of the phenylhydrazones (10) with a sulfonyloxy group at the ortho-position. This method was applied to the first synthesis of the calmodulin antagonist eudistomidin-A (2).

THE IMPROVED SYNTHESIS OF 7-OXYGENATED INDOLES BY FISCHER INDOLIZATION AND ITS APPLICATION TO THE FIRST TOTAL SYNTHESIS OF EUDISTOMIDIN-A

The Fischer indolization of o-sulfonyloxyphenylhydrazones 2b, c was found to give corresponding 7-oxygenated indoles 3 in moderate yields.This method was applied to the first total synthesis of eudistomidin-A 1.