1262633-18-0Relevant academic research and scientific papers
Identifying chelators for metalloprotein inhibitors using a fragment-based approach
Jacobsen, Jennifer A.,Fullagar, Jessica L.,Miller, Melissa T.,Cohen, Seth M.
, p. 591 - 602 (2011/03/21)
Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix meta
