1262675-56-8Relevant academic research and scientific papers
A simple, base-free preparation of S-aryl thioacetates as surrogates for aryl thiols
Van Den Hoogenband, Adri,Lange, Jos H. M.,Bronger, Raymond P. J.,Stoit, Axel R.,Terpstra, Jan Willem
experimental part, p. 6877 - 6881 (2011/03/18)
A mild method for the preparation of S-aryl thioacetates by hetero cross-coupling reactions of aryl bromides or aryl triflates with potassium thioacetate is described. The reaction proceeded smoothly in toluene at 110°C, mediated by catalytic Pd2(dba)3 in combination with CyPF-tBu as the ligand. Neither the presence of a base nor microwave conditions were required. The formed S-aryl thioacetate proved to be stable under flash chromatographic conditions and could be rapidly converted into the corresponding thiol under mildly basic conditions.
