1262681-63-9Relevant academic research and scientific papers
Multistep reactions using microreactor chemistry
Ahmed-Omer, Batoul,Barrow, David A.,Wirth, Thomas
experimental part, p. 26 - 36 (2011/07/07)
A microflow system for the investigation of multistep syntheses involving Pd-catalysed Heck reactions and Ru-catalysed ring-closing metathesis is described. A successful provision of reagent and catalyst delivery in a consecutive fashion allowed control over reaction parameters leading to fast optimisation. The performance of Heck reactions in multistep procedures was not as successful as in the single step coupling, whereas the ring-closing metathesis proved to be successful in the production of the desired compounds for further functionalisation. ARKAT-USA, Inc.
